Protein Details: Chloride channel protein

Protein ID

ICDB_Pro_0400

Protein Name

Chloride channel protein

Gene Name

Organism

Torpedo marmorata (Marbled electric ray)

Length

805 amino acids

AlphaFoldDB

AF-P21564-F1-model_v4.pdb

Function

This channel is thought to ensure the high conductance of the non-innervated membrane of the electrocyte necessary for efficient current generation caused by sodium influx through the acetylcholine receptor at the innervated membrane.

Sequence

MSHEKNEASGYPEAQSWKSQEAMLGARTEVSRWRAVKNCLYRHLVKVLGEDWIFLLLLGALMALVSWAMDFIGSRGLRFYKYLFALVEGNIGLQYLVWVCYPLALILFSSLFCQIVSPQAVGSGIPELKTIIRGAVLHEYLTLRTFVAKTVGLTVALSAGFPLGKEGPFVHIASICATLLNQLLCFISGRREEPYYLRADILTVGCALGISCCFGTPLAGVLFSIEVTCSHFGVRSYWRGFLGGAFSAFIFRVLSVWVKDTVTLTALFKTNFRGDIPFDLQEMPAFAIIGIASGFFGALFVYLNRQIIVFMRKKNFVTKILKKQRLIYPAVVTFVLATLRFPPGVGQFFGAGLMPRETINSLFDNYTWTKTIDPRGLGNSAQWFIPHLNIFIVMALYFVMHFWMAALAVTMPVPCGAFVPVFNLGAVLGRFVGELMALLFPDGLVSNGNLYHILPGEYAVIGAAAMTGAVTHAVSTAVICFELTGQISHVLPMMVAVILANMVAQGLQPSLYDSIIQIKKLPYLPELSWSSANKYNIQVGDIMVRDVTSIASTSTYGDLLHVLRQTKLKFFPFVDTPDTNTLLGSIDRTEVEGLLQRRISAYRRQPAAAAEADEEGRNGETGASFTGEAESSFAYIDQEDAEGQQREGLEAVKVQTEDPRPPSPVPAEEPTQTSGIYQKKQKGTGQVASRFEEMLTLEEIYRWEQREKNVVVNFETCRIDQSPFQLVEGTSLQKTHTLFSLLGLDRAYVTSMGKLVGVVALAEIQAAIEGSYQKGFRLPPPLASFRDVKHARNSGRTATSNSSGK

PDB Structures

2D4Z

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 123; /ligand="chloride" ; BINDING 418; /ligand="chloride" ; BINDING 512; /ligand="chloride"

Disease

Location

DOI ID

10.1038/348510a0; 10.1016/j.str.2005.10.008